Personal Genomics

What This Skill Does

The Personal Genomics skill by wkyleg is a sophisticated, privacy-focused tool designed for comprehensive DNA analysis. Supporting over 1600+ markers across 30 distinct categories, this skill acts as a localized bioinformatics engine for OpenClaw agents. It processes raw data from major testing providers like 23andMe, AncestryDNA, MyHeritage, and FTDNA, as well as standardized VCF (Variant Call Format) files. Beyond simple ancestry, it provides medical-grade insights including pharmacogenomics, hereditary cancer screening, autoimmune HLA typing, and physiological traits like pain sensitivity and sleep optimization.

Installation

To install this skill, use the ClawHub command line interface provided by OpenClaw: clawhub install openclaw/skills/skills/wkyleg/personal-genomics

Use Cases

This skill is ideal for users seeking to understand their biological predispositions without relying on third-party cloud analytics. Use cases include checking how your genetics influence your response to common medications (such as warfarin or omeprazole), exploring your maternal and paternal lineage through detailed haplogroup analysis, or identifying hereditary health risks like Lynch syndrome or BRCA markers. It is also highly useful for athletes or wellness enthusiasts looking to optimize diet and sleep cycles based on verified genetic markers.

Example Prompts

1. "Analyze my 23andMe file in ~/Downloads/dna.txt and tell me if I have any known variants that interact with my current medication, warfarin."
2. "Can you perform a comprehensive hereditary cancer risk assessment using my VCF file?"
3. "Based on my genetics, what does the report say about my caffeine metabolism and sleep chronotype?"

Tips & Limitations

This skill performs local, private analysis—no genetic data is transmitted to external servers. Ensure your input files are in the correct format (tab-delimited rsid or VCF). Always note that this skill is for informational purposes; it does not replace the diagnosis or advice of a medical professional. If a result indicates a serious health risk, always consult with a licensed physician or genetic counselor before making major lifestyle or medication changes. Ensure you have the file paths for your raw genetic data ready before executing the command.