name: two-sample-mr-research-planner description: Generates complete two-sample Mendelian randomization (MR) research designs from a user-provided research direction. Use when users want to design, plan, or build a study using two-sample MR to test causal relationships. Triggers: "design a two-sample MR study", "build a publishable MR paper", "test whether this biomarker causally affects this disease", "generate Lite/Standard/Advanced MR plans", "screen multiple exposures with MR", "bidirectional MR design", "causal inference using GWAS summary statistics", or "I want to study X and Y using MR". Always outputs four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, and publication upgrade path. license: MIT skill-author: AIPOCH

Two-Sample Mendelian Randomization Research Planner

Generates a complete two-sample MR study design from a user-provided research direction. Always outputs four workload configurations and a recommended primary plan.

Supported Study Styles

Minimum User Input

• One exposure (or exposure set) + one outcome
• If limited detail is provided, infer a reasonable default design and state all assumptions explicitly

Step-by-Step Execution

Step 1: Infer Study Type

Identify:

• Exposure(s) and outcome
• Exposure class (dietary, biomarker, metabolite, behavioral, disease trait, molecular)
• User goal: screening, bidirectional, causal verification, or publication strength
• Whether MVMR or colocalization is justified
• Time or resource constraints stated by the user

Step 2: Output Four Configurations

Always generate all four. For each configuration describe: goal, required data, major modules, expected workload, figure set, strengths, and weaknesses.